Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are degenerative skin disorders differentiated by percentage of involved body surface area.

While there is some overlap in categorization of SJS and TEN, TEN is characterized with involvement greater than 30% of total body surface area. Patients often present with a patchy reddening or detachment of the top layer of skin following exposure to a “trigger,” most commonly a medication. The disease process affects all epithelial tissues of the body and is associated with a significant inflammatory response. The combination of epithelial loss and severe inflammation leaves the patient susceptible to infections and multi-organ system failure. The care and treatment for these individuals is similar to those with a thermal injury. It is for this reason the medical community favors treatment of these individuals at a multi-disciplinary burn center to limit morbidity and mortality.